CAPTO adhere-色谱介质-耗材-生物在线
上海基星生物科技有限公司
CAPTO adhere

CAPTO adhere

商家询价

产品名称： CAPTO adhere

英文名称： CAPTO adhere

产品编号： 17-5444-10

产品价格： 0

产品产地： 美国

品牌商标： GE

更新时间： null

使用范围： null

上海基星生物科技有限公司
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进入展台

17-5444-10 CAPTO adhere 25 ML
17-5451-01 Capto Phenyl High Sub 25 ml
17-5459-01 Capto Butyl 25 ml
17-5468-02 Capto SP ImpRes, 100 mL
17-5468-10 Capto SP ImpRes, 25 mL
17-5470-02 Capto Q ImpRes, 100 mL
17-5470-10 Capto Q ImpRes, 25 mL
28-4024-01 PLASMIDSELECT XTRA 25ML
28-4024-02 PLASMIDSELECT XTRA 200ML
28-9032-30 CAPTO ViralQ, 25 ML
28-9032-31 CAPTO ViralQ, 100 ML
17-0420-01 THIOPROPYL SEPHAROSE 6 B   15
17-0430-01 CNBR ACTIVATED SEPHAROSE 4B 1
17-0440-01 CON-A SEPHAROSE 4B   100 ML
17-0440-03 CON-A SEPHAROSE 4B   5 ML
17-0444-01 LENTIL LECTIN-SEPHAROSE 4 B 25
17-0467-01 HEPARIN-SEPHAROSE CL-6B   10 G
17-0480-01 EPOXY ACTIVATED SEPHAROSE 6B
17-0490-01 ACTIVATED CH SEPHAROSE 4B   15
17-0529-01 CALMODULIN-SEPHAROSE 4B, 10 M
17-0568-01 BENZAMIDINE-SEPHAROSE 6B
17-0569-01 EAH-SEPHAROSE 4B, 50 ML
17-0571-01 ECH-SEPHAROSE 4B, 50 ML
17-0575-01 CHELATING SEPHAROSE FAST FLOW
17-0618-01 PROTEIN G SEPHAROSE 4 FF, 5 ML
17-0618-02 PROTEIN G SEPHAROSE 4 FF, 25 M
17-0618-05 PROTEIN G SEPHAROSE 4FF 200 ML
17-0640-01 ACT THIOL SEPHAROSE 4B 15 G
17-0690-01 LYSINE-SEPHAROSE 4B 15 G
17-0700-01 2',5' ADP-SEPHAROSE 4B   5 G
17-0756-01 GLUTATHIONE SEPHAROSE 4B 10 M
17-0756-04 GLUTATHIONE SEPHAROSE 4B, 300
17-0756-05 GLUTATHIONE SEPHAROSE 4B, 100M
17-0780-01 PROTEIN A-SEPHAROSE CL-4B 1.5G
17-0820-01 CNBR ACTIVATED SEPHAROSE 6MB
17-0885-01 GAMMABIND G SEPHAROSE, 5 ML
17-0885-02 GAMMABIND G SEPHAROSE, 25 ML
17-0885-04 GAMMABIND G SEPHAROSE, 250 ML
17-0886-01 GAMMABIND PLUS SEPHAROSE, 5 ML
17-0886-02 GAMMABIND PLUS SEPHAROSE, 25 M
17-0886-04 GAMMABIND PLUS SEPHAROSE, 500
17-0906-01 NHS ACT SEPHAROSE 4 FF 25 ML

Capto adhere/HiTrap Capto adhere

  • Contaminant removal to formulation levels in post protein A purification
  • Prepacked HiTrap columns for easy screening and convenient process development.
  • High capacity and productivity in flow-through mode
  • Wide operational window of pH and conductivity
  • Savings in time and operating costs with a two-step chromatographic process

Capto adhere/HiTrap Capto adhere

Technical Information


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Capto adhere is a strong anion exchanger with multimodal functionality. The multimodal functionality gives a different selectivity compared to traditional anion exchangers. Capto adhere is designed for post Protein A purification of monoclonal antibodies. Removal of leached Protein A, aggregates, host cell proteins, nucleic acids and viruses from monoclonal antibodies is performed in flow-through mode at which the antibodies pass directly through the column while the contaminants are adsorbed. For best performance of Capto adhere, screening/optimization of loading conditions are required.

 

TECHNICAL SPECIFICATIONS - Capto™ adhere
Ion exchanger type  Multimodal strong anion exchanger 
Ionic capacity   0.09 to 0.12 mmol Cl-/ml medium 
Average particle size1  75 μm (d50V) 
Matrix  Highly cross-linked agarose 
Flow velocity2  At least 600 cm/h in a 1-m diameter column with 20-cm bed height at 20°C using process buffers with the same viscosity as water at < 3 bar (0.3 MPa) 
pH-stability3  2 to 14 (short term)
3 to 12 (long term) 
Working temperature4  4°C to 30°C 
Chemical stability5  All commonly used aqueous buffers, 1 M acetic acid, 1 M sodium hydroxide 
Avoid  Oxidizing agents, anionic detergents 
Storage  20% ethanol 
Storage temperature  4°C to 30°C 
1 d50v is the median particle size of the cumulative volume distribution.
2 The capacity for selective removal of some key contaminants may decrease at high flow velocity.
3 Short term pH: pH interval where the medium can be subjected to, for cleaning- or sanitization-in-place.
Long term pH: pH interval where the medium can be operated without significant change in function.
4 Capto adhere can be used under cold-room conditions, but the capacity for some key contaminants may decrease.
5 No significant change in ionic binding capacity and carbon content after one week storage in 1 M NaOH at 40°C.

 

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