Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. *   http://www.creative-diagnostics.com/Anti-HDAC6-PAb-188265-147.htm