CD40 monoclonal antibody, clone BE-1
产品名称: CD40 monoclonal antibody, clone BE-1
英文名称: CD40 monoclonal antibody, clone BE-1
产品编号: MAB6911
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native CD40.
- Immunogen:
- Native purified CD40 from murine L cells.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody binds with cross linked BE-1 will partially activate B cells.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
- Storage Instruction:
- Store at 4°C.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Assembly and regulation of the CD40 receptor complex in human B cells.
Kuhne MR, Robbins M, Hambor JE, Mackey MF, Kosaka Y, Nishimura T, Gigley JP, Noelle RJ, Calderhead DM.J Exp Med. 1997 Jul 21;186(2):337-42.
- 2.
- Immune regulation by CD40 and its ligand GP39.
Foy TM, Aruffo A, Bajorath J, Buhlmann JE, Noelle RJ.Annu Rev Immunol. 1996;14:591-617.
- 3.
- Analysis of expression and function of CD40 on normal and leukemic human B cell precursors.
Law CL, Wormann B, LeBien TW.Leukemia. 1990 Nov;4(11):732-8.
- Application Image
- Immunohistochemistry (Frozen sections)
- Immunoprecipitation
- Flow Cytometry
- Entrez GeneID:
- 958
- Gene Name:
- CD40
- Gene Alias:
- Bp50,CDW40,MGC9013,TNFRSF5,p50
- Gene Description:
- CD40 molecule, TNF receptor superfamily member 5
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- B cell surface antigen CD40,B cell-associated molecule,CD40 antigen,CD40 antigen (TNF receptor superfamily member 5),CD40 type II isoform,CD40L receptor,OTTHUMP00000031699,OTTHUMP00000031700,nerve growth factor receptor-related B-lymphocyte activation mol
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